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Year Number of Results
1976 3
1977 1
1978 1
1983 2
1985 2
1986 3
1987 3
1988 1
1989 1
1990 1
1991 4
1992 4
1994 4
1995 4
1996 4
1997 6
1998 2
1999 7
2000 5
2001 10
2002 9
2003 8
2004 12
2005 12
2006 13
2007 13
2008 17
2009 21
2010 19
2011 20
2012 18
2013 26
2014 28
2015 22
2016 22
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2019 36
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2023 42
2024 20

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522 results

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The following term was ignored: []
The following term was not found in PubMed: nsubstratum
Page 1
The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K.
Słabicki M, Kozicka Z, Petzold G, Li YD, Manojkumar M, Bunker RD, Donovan KA, Sievers QL, Koeppel J, Suchyta D, Sperling AS, Fink EC, Gasser JA, Wang LR, Corsello SM, Sellar RS, Jan M, Gillingham D, Scholl C, Fröhling S, Golub TR, Fischer ES, Thomä NH, Ebert BL. Słabicki M, et al. Nature. 2020 Sep;585(7824):293-297. doi: 10.1038/s41586-020-2374-x. Epub 2020 Jun 3. Nature. 2020. PMID: 32494016 Free PMC article.
Molecular glue compounds induce protein-protein interactions that, in the context of a ubiquitin ligase, lead to protein degradation(1). Unlike traditional enzyme inhibitors, these molecular glue degraders act substoichiometrically to catalyse the rapid depletion of …
Molecular glue compounds induce protein-protein interactions that, in the context of a ubiquitin ligase, lead to protein degradation( …
Rational discovery of molecular glue degraders via scalable chemical profiling.
Mayor-Ruiz C, Bauer S, Brand M, Kozicka Z, Siklos M, Imrichova H, Kaltheuner IH, Hahn E, Seiler K, Koren A, Petzold G, Fellner M, Bock C, Müller AC, Zuber J, Geyer M, Thomä NH, Kubicek S, Winter GE. Mayor-Ruiz C, et al. Nat Chem Biol. 2020 Nov;16(11):1199-1207. doi: 10.1038/s41589-020-0594-x. Epub 2020 Aug 3. Nat Chem Biol. 2020. PMID: 32747809 Free PMC article.
However, their discovery has so far been serendipitous, thus hampering broad translational efforts. Here, we describe a scalable strategy toward glue degrader discovery that is based on chemical screening in hyponeddylated cells coupled to a multi-omics target deconvolutio …
However, their discovery has so far been serendipitous, thus hampering broad translational efforts. Here, we describe a scalable strategy to …
Bronchial artery embolization in hemoptysis: a systematic review.
Panda A, Bhalla AS, Goyal A. Panda A, et al. Diagn Interv Radiol. 2017 Jul-Aug;23(4):307-317. doi: 10.5152/dir.2017.16454. Diagn Interv Radiol. 2017. PMID: 28703105 Free PMC article. Review.
Most common embolizing agent used was polyvinyl alcohol (size, 300-600 mum) with increasing use of glue in recent years. Overall immediate clinical success rate of BAE, defined as complete cessation of hemoptysis, varied from 70%-99%. ...Despite high hemoptysis recurrence …
Most common embolizing agent used was polyvinyl alcohol (size, 300-600 mum) with increasing use of glue in recent years. Overall imme …
Anatomy, Skin (Integument), Epidermis.
Yousef H, Alhajj M, Sharma S. Yousef H, et al. 2022 Nov 14. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2022 Nov 14. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 29262154 Free Books & Documents.
The lamellar granules contain the glycolipids that get secreted to the surface of the cells and function as a glue, keeping the cells stuck together. Stratum lucidum, 2-3 cell layers, present in thicker skin found in the palms and soles, is a thin clear layer consisting of …
The lamellar granules contain the glycolipids that get secreted to the surface of the cells and function as a glue, keeping the cells …
Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation.
Lv L, Chen P, Cao L, Li Y, Zeng Z, Cui Y, Wu Q, Li J, Wang JH, Dong MQ, Qi X, Han T. Lv L, et al. Elife. 2020 Aug 17;9:e59994. doi: 10.7554/eLife.59994. Elife. 2020. PMID: 32804079 Free PMC article.
Molecular-glue degraders mediate interactions between target proteins and components of the ubiquitin-proteasome system to cause selective protein degradation. ...Structure-activity relationship analysis of HQ461 revealed the importance of a 5-methylthiazol-2-amine pharmac …
Molecular-glue degraders mediate interactions between target proteins and components of the ubiquitin-proteasome system to cause sele …
Treatment of upper gastrointestinal bleeding in 2020: New techniques and outcomes.
Lau LHS, Sung JJY. Lau LHS, et al. Dig Endosc. 2021 Jan;33(1):83-94. doi: 10.1111/den.13674. Epub 2020 May 20. Dig Endosc. 2021. PMID: 32216134 Review.
Over-the-scope clips have high success rates as rescue or even first-line treatments in difficult-to-treat cases. Hemostatic powder is safe and easy to use, which can be useful as temporary control with its high immediate hemostatic ability. ...In refractory bleeding, angi …
Over-the-scope clips have high success rates as rescue or even first-line treatments in difficult-to-treat cases. Hemostatic powder i …
Wound Closure Techniques.
Azmat CE, Council M. Azmat CE, et al. 2023 Jun 26. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2023 Jun 26. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 29262163 Free Books & Documents.
Care should be taken when applying these sutures as to the depth of the wound because they can form a potential cavity beneath the suture line if the wound is deep. Adhesives In percutaneous wounds or simple pediatric cases, skin glues are particularly useful as they are q …
Care should be taken when applying these sutures as to the depth of the wound because they can form a potential cavity beneath the suture …
Lenalidomide derivatives and proteolysis-targeting chimeras for controlling neosubstrate degradation.
Yamanaka S, Furihata H, Yanagihara Y, Taya A, Nagasaka T, Usui M, Nagaoka K, Shoya Y, Nishino K, Yoshida S, Kosako H, Tanokura M, Miyakawa T, Imai Y, Shibata N, Sawasaki T. Yamanaka S, et al. Nat Commun. 2023 Aug 18;14(1):4683. doi: 10.1038/s41467-023-40385-9. Nat Commun. 2023. PMID: 37596276 Free PMC article.
Lenalidomide, an immunomodulatory drug (IMiD), is commonly used as a first-line therapy in many haematological cancers, such as multiple myeloma (MM) and 5q myelodysplastic syndromes (5q MDS), and it functions as a molecular glue for the protein degradation of neosu …
Lenalidomide, an immunomodulatory drug (IMiD), is commonly used as a first-line therapy in many haematological cancers, such as multi …
Pythium Keratitis.
Gurnani B, Kaur K. Gurnani B, et al. 2023 Jul 17. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2023 Jul 17. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 34424645 Free Books & Documents.
The medical management options available are antifungals, antibacterials, and cyanoacrylate glue. The antibacterials in the form of linezolid and azithromycin have shown higher in-vitro efficacy against the organism. Hence they are considered first-line drugs for Py …
The medical management options available are antifungals, antibacterials, and cyanoacrylate glue. The antibacterials in the form of l …
Gastric variceal bleeding.
Bazarbashi AN, Ryou M. Bazarbashi AN, et al. Curr Opin Gastroenterol. 2019 Nov;35(6):524-534. doi: 10.1097/MOG.0000000000000581. Curr Opin Gastroenterol. 2019. PMID: 31577562 Review.
Endoscopic management of acute gastric variceal bleeding has been premised on the injection of sclerosants and synthetic glue. However, these therapies are associated with various complications including systemic embolization and recurrent bleeding. ...However, EUS-guided …
Endoscopic management of acute gastric variceal bleeding has been premised on the injection of sclerosants and synthetic glue. Howeve …
522 results